[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Names and Identifiers

Name	Terazosin HCL dihydrate
Synonyms	SPBio_002701 SMR000058309 Terazosin HCl Prestwick0_000751 Prestwick1_000751 Terazosin HCL dihydrate Terazosin hydrochloride IMP terazosin hydrochloride dihydrate Terazosine Hydrochloride Dihydrate Terazosin Hydrochloride Impurity Ⅴ arbonyl)-,monohydrochloride,dihydrate Terazosin monohydrochloride dihydrate 2-chloro-4-amino-6,7-dimethoxyquinazolin 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)pipera zine 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2- furanyl)carbonyl)- [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone 4-Amino-6,7-dimethoxy-2-[4-(tetrahydro-2-furoyl)-1-piperazinyl]quinazoline Hydrochloride 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furanyl-)carbonyl)-piperazine hydrochloride dihydrate [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone hydrochloride dihydrate
CAS	70024-40-7
EINECS	629-697-5
InChI	InChI=1/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Physico-chemical Properties

Molecular Formula	C19H30ClN5O6
Molar Mass	459.92
Melting Point	271-274°C
Boling Point	664.5°C at 760 mmHg
Flash Point	355.7°C
Solubility	Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent), practically insoluble in acetone.
Vapor Presure	1.59E-17mmHg at 25°C
Appearance	neat
Color	White
Storage Condition	Sealed in dry,Room Temperature
MDL	MFCD00941408
Physical and Chemical Properties	Melting point 271-274°C
Use	An α1-selective blocker
In vitro study	In prostate cancer cells, Terazosin causes a significant loss of cell viability by inducing apoptosis. Terazosin inhibits prostate growth through α1-adrenoceptor independent action, further supporting another study, Doxazosin inhibits human vascular smooth muscle cell proliferation, independent of α1-adrenoceptor antagonism. In Xenopus oocytes, Terazosin blocked the HERG current with an IC 50 of 113.2 mM, while in human HEK293 cells, Terazosin blocked the HERG channel with an IC 50 of 17.7 mM. Terazosin or genistein inhibited DU-145 cell growth in a dose-dependent manner, while had no effect on normal prostatic epithelial cells. Terazosin caused genistein-induced DU-145 cell arrest at G2/M phase, an increase in apoptotic cells, as evidenced by procaspase-3 activation and PARP cleavage. Terazosin induced cytotoxicity in PC-3 and human benign prostate cells with an IC 50 of 100 mM.
In vivo study	In nude mice, Terazosin significantly inhibited vascular endothelial growth factor-induced angiogenesis with an IC50 of 7.9 mM, showing that it has a more potent anti-angiogenic effect than the cytotoxic effect. Terazosin also effectively inhibited vascular endothelial growth factor-induced proliferation and tube formation in human umbilical vein endothelial cells with IC50 of 9.9 and 6.8 mM, respectively.

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
RTECS	TK8046000
HS Code	2934990002
Toxicity	LD50 in male, female rats (mg/kg): 277, 293 i.v. (Fort)

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Reference

Reference

1. Zhang, Man, et al. "Micelles self-assembled by 3-O-β-d-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy." Journal of nanobiotechnology 18.1 (2020): 1-15.

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Introduction

Terazosin HCl dihydrate are alpha-adrenergic receptor inhibitors for the treatment of hypertension and prostatic hypertrophy.

Last Update：2022-10-16 17:28:03

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone

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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: Terazosin Hydrochloride Dihydrate Visit Supplier Webpage Request for quotation
CAS: 70024-40-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Terazosin HCL dihydrate Request for quotation
CAS: 70024-40-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: Terazosin Hydrochloride Dihydrate Visit Supplier Webpage Request for quotation
CAS: 70024-40-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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View History

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
1H-Azeto[1,2-a]pyrrolo[3,4-c]pyrrole(9CI)
N,O-二BOC-羟胺

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone

Terazosin HCL dihydrate

CAS: 70024-40-7

Molecular Formula: C19H30ClN5O6

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Names and Identifiers

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Physico-chemical Properties

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Risk and Safety

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Reference

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Introduction

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[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone Request for Quotation

Terazosin HCL dihydrate

CAS: 70024-40-7

Molecular Formula: C19H30ClN5O6

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Names and Identifiers

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Physico-chemical Properties

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Risk and Safety

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Reference

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone - Introduction

Supplier List

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone